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Cephalosporin

Cephalosporin is the second class of β-Lactamase found in nature following by penicillin. Any of various broad-spectrum antibiotics, closely related to the penicillins, which were originally derived from the fungus Cephalosporium acremonium. It has many advantages of high efficiency, broad-spectrum, low toxicity and enzyme-resistance which has been developed four new products to its range. It belongs to superior antibiotics that its application is growing widely. Advanced production technique is very pressing to meet brisk demands of the market both domestically and internationally. Cephalosporin C, or simply as CPC, is the source of original nuclear（7-amino cephalosporanic acid）of various cephalosporium antibiotic.

During the production of CPC, frame filter press, rotate vacuum drum filter are still used as a means of separation to remove protein, mycelium, and solid particulates. The technical means available on site did not achieve satisfactory degrees of separation. Meanwhile, those methods are unable to separate the massive existences of soluble protein, macro-molecule organic matters from the broth. The filtered broth shows not high transmittance with residual insolubility and soluble impurities which would increase the difficulty in the downstream extraction process and have a bad effect on the quality and yield of final product. According to market adjusting, some companies are asked to improve separation performance by means of membrane technology and to reduce the product losses. With the wide applications of ceramic membranes, they will play a significant role in separation and purification of antibiotics.

Three steps are introduced in order to guarantee the yield of CPC in the process of filtrate fermentation broth for the production of CPC by ceramic membranes. Pre-concentration step is made to let feed volume Vo concentrate to Vd and permeates are obtained meanwhile; diafiltration step is to add cleaning agents in the wanted liquids while filtration and effective ingredients are got to reach a high yield ; post-concentration step is to concentrate wanted liquids to Ve aiming to treat residuals conveniently and improve yield further.

Ceramic membrane for fermentation filtration system could intercept protein and solid particulates from the untreated antibiotic fermentation broth. The protein –removing the capability of this technology is 10 times as much as that of the original process, with filtration yield increasing by 6％. The attenuation range of membrane flow rate is narrow and thus a better product quality can be obtained.

The temperature of CPC fermentation broth from the fermented process drops to 10 below zero and it is acidified to pH2.5-3.0 by the use of hydrofluoric acid.

Then CPC clarity is got due to removing mycelium, suspended solids, and macromolecular protein through the filtration process. In the next refining process, macroporous resin adsorption and ion-exchange are applied, and then nanofiltration and reverse osmosis are also used to obtain concentrated CPC.

 Spectinomycin

Spectinomycin is an older antibiotic from S. spectabilis whose structure contains an unusual tricyclic ring. Spectinomycin is sold under the tradename Trobicin among others, is an antibiotic useful for the treatment of gonorrhea infections. It is given by injection into a muscle.

In the process of spectinomycin bio-fermentation, there are many bacteria, protein, macromolecular pigment, insoluble starch and sub-micron particles in the fermentation broth. The presence of these impurities can cause blocking in the post-ion exchange adsorption or pollution in the post-extraction, affect the extraction and purification efficiency and lead to the decline of the quality of follow-up products, and even feed contamination, resulting in product scrap, so industrial production must be separated to remove such impurities.

Clarification fermentation broth is usually done by plate frame filtration, vacuum drum filtration, diatomaceous earth filtration, centrifugation, and other methods.

However, neither of these methods can completely and effectively separate the impurities in the fermentation broth, which can easily cause blockage and frequent replacement of the filter medium, thereby affecting work efficiency.

With many years of experience in filtration and membrane separation technology  in the pharmaceutical industry, ceramic membrane filtration technology and organic membrane filtration technology are successfully applied to fermentation broth clarification process to solve the problem of clarification in the production of fermentation broth which achieves the goal of simplifying process, convenient operation, clean production requirements and development of advanced scientific and technological innovation.

 Erythromycin

Erythromycin is a macrolide antibiotic that has an antimicrobial spectrum similar to or slightly wider than that of penicillin and is often used for people who have an allergy to penicillins.

Erythromycin is mainly fermentation production. As the fermentation broth contains a large number of mycelium, protein and polysaccharide material, to the separation and extraction of erythromycin caused difficulties affecting their yield and quality. Therefore, before the separation and extraction of the fermentation broth need pretreatment. At present, a more commonly used method is flocculation and high-speed centrifuge. The former sterilization rates are relatively high, but the removal of proteins and polysaccharides less effective, resulting in a high solution viscosity, affecting the crystallization process of the follow-up; the latter large energy consumption, equipment is expensive, in the actual production is difficult to wider application.

During the production of erythromycin, frame filter press, rotate vacuum drum filter are still used as a means of separation to remove protein, mycelium, and solid particulates. The technical means available on site did not achieve satisfactory degrees of separation. Meanwhile, those methods are unable to separate the massive existences of soluble protein, macro-molecule organic matters from the broth. The filtered broth shows not high transmittance with residual insolubility and soluble impurities which would increase the difficulty in the downstream extraction process and have a bad effect on the quality and yield of final product. According to market adjusting, some companies are asked to improve separation performance by means of membrane technology and to reduce the product losses. With the wide applications of ceramic membranes, they will play a significant role in separation and purification of antibiotics.

Features of ceramic membrane systems

Continuous operation mode, allowing continuous feed, permeate and concentration

Fully automatic control system

Accurate diafiltration process

CIP system

Applicable for filtration at high temperature

Mechanically strong, highly resistant to wide ranges of pH values, and resistant to acids, caustic, organic solvents and strong oxidants;

High concentration factor, low water consumption, and small waste discharge

Integrated Ultrafiltration and Nanofiltration  is a separation in recent decades developed a new technology, better removal of macromolecules such as proteins and polysaccharides. With this technology, the usage of exacting solvent and de-emulsifier will be greatly minimized, reducing the load on the followed high-speed centrifuge, solvent recycles and treatment of waste solids and wastewater. Moreover, NF permeates could be recycled directly as UF diafiltration water, extensively reducing the consumption of water and the load on wastewater treatment.

 Lincomycin

Lincomycin is a lincosamide antibiotic that comes from the actinomycete Streptomyces lincolnensis.

A related compound, clindamycin, is derived from lincomycin by using thionyl chloride to replace the 7-hydroxy group with a chlorine atom with inversion of chirality

Process

Fermentation pretreatment

Solvent extraction

Bleaching

Crystallization

Drying

Final product

Colistin sulphate

Colistin sulphate, also known as polymyxin E, is an antibiotic produced by certain strains of the bacteria Paenibacillus polymyxa. Colistin sulphate is a mixture of the cyclic polypeptides colistin A and B and belongs to the class of polypeptide antibiotics known as polymyxins. Colistin sulphate is effective against most Gram-negative bacilli.

Colistin sulphate Separation and Purification technology is suitable for industrial production of modern antibiotics using microbial synthesis, which can replace traditional purification technologies such as adsorption, precipitation, solvent extraction and ion exchange.

Separation process provides optimum solutions with the unique characteristics without any chemical reaction, no phase change, does not destroy the biological activity, environment-friendly.

 CLAVULANIC ACID

Clavulanic acid is a β-lactam drug that functions as a mechanism-based β-lactamase inhibitor.

In the process of clavulanic acid bio-fermentation, there are many bacteria, protein, macromolecular pigment, insoluble starch and sub-micron particles in the fermentation broth. The presence of these impurities can cause blocking in the post-ion exchange adsorption or pollution in the post-extraction, affect the extraction and purification efficiency and lead to the decline of the quality of follow-up products, and even feed contamination, resulting in product scrap, so industrial production must be separated to remove such impurities.

Clarification fermentation broth is usually done by plate frame filtration, vacuum drum filtration, diatomaceous earth filtration, centrifugation and other methods.

However, neither of these methods can completely and effectively separate the impurities in the fermentation broth, which can easily cause blockage and frequent replacement of the filter medium, thereby affecting work efficiency.

With many years of experience in filtration and membrane separation technology in the pharmaceutical industry, ceramic membrane filtration technology and organic membrane utrafiltration technology are successfully applied to fermentation broth clarification process to solve the problem of clarification in the production of fermentation broth which achieves the goal of simplifying process, convenient operation , clean production requirements and development of advanced scientific and technological innovation.

JIUWU HI-TECH has many unique china membrane applications and more than 50 Patents regarding ceramic membranes, systems and process applications, in areas such as Food & Beverage, Bio-Pharm, Environmental and the Chemical Industry. We sincerely invite and welcome people from all around the world to invest and create more values together.

Palm oil is not only the highest yielding cheap vegetable oil on the earth but also a safe raw material for edible oils and daily chemicals, and a raw material for biofuel.

As a raw material for edible vegetable oils, chemical raw materials and biofuel, palm oil has attracted worldwide attention in the process of ecological protection and industrial pollution. As a result, palm oil wastewater treatment also receives much attention.

Palm oil mill effluent (POME)is a yellow liquid with a unique unpleasant smell and comes from oil extraction, cleaning and washing process in the POME factory, which is featured with very high COD and BOD.

Due to its acidic nature (pH 3.4–5.2), high salt and suspended solids, oil and grease, the untreated discharge of POME can result in considerable environmental consequences.

Each ton of palm oil produced emits about 20 tons of high-concentration organic wastewater. When the high-concentration organic wastewater per ton is treated according to the current sewage pond treatment method, it is equivalent to emitting more than 210 million tons of carbon dioxide gas into the atmosphere every year. It's important to solve the problems in palm oil mill effluent treatment.

To achieve environmental requirements and economic challenges, the POME factories are trying to get efficient and return on the investment process.

JIUWU HI-TECH has made a lot of studies and many rich experiences for POME treatment since 2012.

JIUWU HI-TECH offers the solution for POME treatment with an integrated ceramic membrane technology which is a green, friendly environment, economic efficiency and has the following technical benefits:

No discharge of wastewater

Low capital investment ;

Low operation cost;

Oil is concentrated and water is recycled

After integrated process filtration, concentrate including surplus sludge from anaerobic and centrifuge is used as fertilizer for cattle farm and purified water can be used for recycling or the bolier feed water due to salts and organic compounds are removed.

JIANGSU JIUWU HI-TECH CO. LTD.,founded in 1997, focus on producing Organic membrane filters for many years. And JIUWU HI-TECH has become a leading company in the membrane separation industry. We sincerely invite and welcome people from all around the world to invest and create more values together.

Although batch processes are currently used, a number of more advanced techniques have been investigated in order to improve the process efficiency of organic acid fermentation. Promising every result must have been achieved using the tangential flow filtration in the continuous fermentation systems.

One of the main advantages of tangential flow filtration is that the higher biomass concentrations are possible because cells are continuously recycled back to the fermentor. A dense population of cells not only accelerates production of lactic acid but also minimizes contamination by foreign microorganisms. Thus high cell density continuous systems could increase the efficiency of lactic acid production. It can also be applied to nictric acid production.

Lactic acid fermentation broth on the main performance of the membrane fouling is

1. Gel polarization fouling of, membrane surface. Lactic acid fermentation broth by centrifuge coarse filters, except for a small amount of mycelium and solids, but also contains a lot of protein, sugar and easily carbonized material. During the membrane filtration process of lactic acid purification, these substances are easily deposited on the membrane surface and formed gel polarization fouling.

1. Membrane pore adsorption, crystallization pollution. Adding an excess of calcium carbonate is to adjust the system pH, in this way, the excess calcium carbonate is easily occurred crystallization within the hole and in the membrane surface. In the actual operation, the pipeline can easily generate a short temperature difference due to the solubility of calcium lactate which is very sensitive to temperature, so the calcium lactate is also vulnerable to precipitation surface or deposition within the membrane hole and in the membrane surface.

In order to remove impurities, ceramic membrane contamination mechanism in the process of lactic acid fermentation comes down to mycelium, protein, sugar and gel polarization pollution caused by carbonized material in the membrane surface of the and crystallization pollution of calcium carbonate - calcium lactate within the hole and membrane surface.

JIANGSU JIUWU HI-TECH CO. LTD.,founded in 1997, focus on producing ceramic membrane filters for many years. And JIUWU HI-TECH has become a leading company in the membrane separation industry. We sincerely invite and welcome people from all around the world to invest and create more values together.

Membrane filtration principle

Membrane filtration technology is based on a selective filtration through a pressure-driven membrane for sulfate water treatment. The membrane has charged groups that selectively reject multivalent anions such as SO42-. The membrane does not separate monovalent ionic species such as Cl- or CLO3- from the feed solution.

To maximize the membrane area within a compact space, the membranes are packaged as cylindrical elements in a spiral wound configuration.

Feed brine floods the entire feed side of the membrane surface within the membrane element by flowing within a mesh spacer. Brine then permeates through the membrane, where the sulfate is rejected, and flows in a spiral pattern through the permeate carrier, towards the perforated perforated permeate tube.

To achieve the required membrane area, several membrane elements are packed into several high-pressure housing. The high-pressure housings are arranged in series to provide the required number of stages to concentrate the sodium Sulfate solution.

The ceramic membrane filtration unit usually treats dechlorinated depleted brine from the chlor-alkali electrolyzer. It is at this location that athe Na2SO4 concentration is at its highest and the NaCL concentration is at its lowest. Normally only a portion of the dechlorinated brine flow needs to be passed through Sulfate removal system, the remainder bypasses the Sulfate removal unit and is returned to the saturators.

Features:

1. Reduced purge of depleted brine

Substantial costs saving due to less NaCL loss

More Environmental friendly, less effluent

2. No secondary pollution

No need to use BaCl2 reagent which is toxic

No Barium treatment cost

No solid BaSO4 waste

3. No secondary pollution

Lower operating costs

Reduces effluent volume

Full recovery of sulfate and sodium chloride

Proven technology with many references

JIANGSU JIUWU HI-TECH CO. LTD.,founded in 1997, focus on producing ceramic membrane purification for many years. And JIUWU HI-TECH has become a leading company in the membrane separation industry. We sincerely invite and welcome people from all around the world to invest and create more values together.

The pretreatment workshop of Lithium extraction process adopts the international leading gradient coupling membrane separation technology, and the potassium fluoride from salt pans is subjected to magnesium-lithium separation and lithium concentration process to obtain high-purity lithium-rich brine, and is sent to the lithium plant to produce battery-grade lithium carbonate. The operation of the membrane equipment is fully automatic, the lithium yield can reach 80%, and it is at the leading level in the lithium recovery from brines.

The process flow chart of the pretreatment workshop

The potassium fluoride from salt pans is thoroughly mixed with the fresh water sent from the boundary area to reduce the magnesium ion concentration in the brine and then sent to the pre-treatment unit. In the pretreatment unit, the brine is removed by sand filtration to remove large particles of impurities and then sent to an ultrafiltration filter to remove all solid suspended matter. The pretreated purified brine is mixed with the fresh water reused in the workshop to further reduce the ion concentration and sent to the magnesium-lithium separation unit. In the brine purification process, it is separated into magnesium in the brine by a nano-scale membrane separation process in a magnesium-lithium separation unit to reduce the ratio of magnesium to lithium produced by the brine, and the high-magnesium old halogen is converted into a pure lithium chloride solution, and then sent to a lithium chloride primary concentration unit. The primary concentration unit uses a reverse osmosis membrane to concentrate the lithium chloride solution to increase the concentration of lithium chloride, and at the same time, fresh water is recycled to the former unit for dilution of the brine to achieve an internal balance of production water. The concentrated lithium chloride solution concentrated by the reverse osmosis membrane enters the secondary concentration unit, and the unit is further concentrated by the electrodialysis membrane to concentrate the lithium chloride concentrated water, and finally, the lithium-rich brine is sent to the sinking lithium workshop to produce battery-grade lithium carbonate.

Technical advantage analysis

The high-precision anti-pollution ceramic ultrafiltration membrane is used to purify the brine water, which can remove all solid suspended matter in the brine. The water recovery rate is high, the regeneration is easy, the service life is long, and the long-term stable operation can be maintained under the complicated salt lake brine condition.

The imported magnesium-lithium separation special membrane has high separation efficiency, low magnesium content, unique lithium enrichment effect, low lithium content in the outer row, and low lithium loss.

The imported reverse osmosis concentrated membrane has high ion rejection rate, good lithium concentration effect, no phase change in the concentration process, no steam consumption, and low energy consumption.

The imported electrodialysis membrane has high concentration efficiency, stable performance, long service life, no consumption of chemical agents, low operating cost, simple equipment, and high automation.

The process is simple, the equipment is compact, the degree of automation is high, the equipment selection standard is high, and no human intervention is required during the operation, and the equipment runs stable.

JIANGSU JIUWU HI-TECH CO. LTD.,founded in 1997, focus on producing Organic membrane filters for many years. And JIUWU HI-TECH has become a leading company in the membrane separation industry. We sincerely invite and welcome people from all around the world to invest and create more values together.

APPLE JUICE

Apple juice in the press process will bring a lot of impurities in pulp, pectin, starch, plant fiber, microorganisms, bacteria, and other impurities. Thus, it's not easy to produce apple juice concentrate through traditional methods. Due to high sugar content in apple juice, microorganisms and bacteria are easy to breed which makes apple juice fermentation ferment and deteriorate.

High-temperature sterilization will result in product discoloration and loss of flavor. The traditional filtration methods (diatomaceous earth, framed filter) can not completely retain the impurities, can play a temporary clarification. Under the influence of time, temperature, charge,re-flocculation of dissolved impurities form visible matters, resulting in apple juice turbidity and precipitation.

Macromolecular impurities such as plant fiber, starch, bacteria and other impurities in apple juice are completely intercepted to realize the clarification and impurity removal of apple juice by crossflow microfiltration.

Cross-flow design is adopted to solve the problem of filter clogging and will greatly improve the efficiency of producing juice concentrate.

Advantages:

Filtrate is clear with high transmittance

Return muddy does not happen for a long time

No secondary precipitation produced

No need to add a filter aid

Purely physical operation at room temperature

No chemical reaction

Does not destroy the heat-sensitive substances and affect the fruit flavor easy to use

Reduce labor intensity and production costs

Increase productivity

Small footprint

Sanitary material

CIDER JUICE

Ceramic membrane filtration can also be used to produce cider juice, such as apple cider juice.

PEAR JUICE

In the fruit juice industry, fruit juice membrane technology is used mainly to clarify the juice by means of ceramic ultrafiltration and microfiltration and to concentrate it by means of nanofiltration and reverse osmosis.

We look at enzyme immobilization techniques to improve filtration performance and operation methods to quantify fouling.

Membrane fouling is a critical issue and inhibits the broader application of membranes in the fruit production industry. Pectin and its derivatives form a gel-like structure over the membrane surface, thereby reducing the permeate flux. In order to degrade pectin, the raw juice is usually subjected to an enzymatic treatment with pectinase, which hydrolyzes pectin and causes its protein complexes to flocculate. The resulting juice has reduced viscosity and much lower pectin content, which is advantageous in the subsequent filtration processes.

MUSHROOM JUICE

Mushroom is a common edible fungus in life, rich in protein, 18 kinds of amino acids, vitamins and calcium, iron and other minerals.

However, mushroom's respiration is exuberant after picking. The mushroom quickly becomes browning and changing taste at room temperature and is only for short-term storage. Dried mushrooms are easy to preserve, but the nutritional value is reduced. If you want to store for a long time, you need a higher condition, even in these special circumstances, it is easy to be infected by microorganisms and spoilage, which greatly affects its nutritional value.

After the mushroom is processed into mushroom juice, it not only reduces the storage cost, but also is convenient to eat, and keeps the original nutrients of mushroom. This is the latest type of fruit and vegetable juice drink.

LUCERNE JUICE

With the development of science and technology, the research on lucerne has been deeply studied, and the nutrition and health function of lucerne have been highly evaluated. Due to rich crude protein cellulose, vitamins, minerals, and complete amino acid composition, it is a worth developing juice in the beverage field.

VEGETABLE JUICE

Membrane separation processes are widely used in the production of beverage materials and the treatment of water for drinking. The technology can be applied to deacidify, debitter, clarify, concentrate and filter vegetable juices.  It plays an important role in the improvement of product quality, the increase in output and the decrease in production cost.

Vegetable juices are used due to convenience. The juices are rich in various minerals, vitamins, and other nutrients. To process the juices and their clarification and/or concentration is required. The membranes are being used for these purposes. These processes are preferred over others because of high efficiency and low temperature.

Membranes and their characteristics have been proved for knowing suitability of membranes for vegetable juices. Membrane separation is low-temperature process in which the organoleptic quality of the juice is almost retained.

Ultra filtration method combined with the enzyme treatment method than conventional vegetable production's strength lies in

Cost saving clarifying agent

Clarity increases

Cost saving aid

Reduce cost centrifuge, filter, reaction tanks

Save enzyme amount

Reduce process losses

Stable and reliable quality

Continuous operation

Small footprint

Simple operation & maintenance

JIANGSU JIUWU HI-TECH CO. LTD.,founded in 1997, focus on producing ceramic membrane filters for many years. And JIUWU HI-TECH has become a leading company in the membrane separation industry. We sincerely invite and welcome people from all around the world to invest and create more values together.

What is membrane technology in food processing?

Ceramic membrane has high separation efficiency and good chemical stability, which can be used for separation, clarification, purification, and so on. Due to its good performance, ceramic membrane is widely used in the processing of food and beverage. Ceramic membrane filtration can be used for sweetener's concentration and purification. It can also be used to produce concentrated milk proteins and isolated milk proteins. Crossflow filtration is widely used in purify liquids, such as wine, fruit and vegetable juice. Membrane separation technology is used to eliminate bacteria in milk. Ceramic membrane is also extensively used in the processing of flavoring and seasoning, natural herb extract, enzyme and so on. Ceramic membrane can greatly satisfy your needs in food and beverage processing!

Sweetener

Membrane filtration and continuous ion exchange technology: reform sweetener production process.

Wine

Crossflow membrane filtration for wine clarification solution is an ideal way for wineries.

Fruit And Vegetable Juice

Improving quality and cutting down costs by membrane filtration are your wise choice.

Dairy

Producing quality dairy products with less nutrients loss and long shelf life is your need.

Flavoring And Seasoning

Ceramic membrane filtration technology for condiments is an effective, advanced and clean clarification solution.

Natural Herb Extract

Ceramic membrane and organic membrane combination process are becoming a preferred process.

Enzyme

Our ceramic membrane filtration system is to enhance quality and drive down costs.

Non-Alcohol Beer And No Alcohol Wine

The latest extraction technology for non-alcoholic and non-alcoholic wines.

JIANGSU JIUWU HI-TECH CO. LTD.,founded in 1997, focus on producing ceramic membrane for many years. And JIUWU HI-TECH has become a leading company in the membrane separation industry. We sincerely invite and welcome people from all around the world to invest and create more values together.

CHEESE, MILK, WHEY AND FOOD PROTEIN

Concentrated milk proteins (MPCs) and isolated milk proteins (MPIs) are produced by ceramic membrane filtration system and their dairy proteins are separated from fresh skim milk. They combine rich calcium with good thermal stability and refreshing mouthfeel. They are rich in casein and whey protein in the same proportions as skim milk.

Milk protein concentrates are widely used and are ideal for cheese products, artificial products, dairy drinks, infant nutrition, medical nutrition products (enteral foods), weight management products, powdered dietary supplements and sports nutrition products.

In general, milk protein concentrates provide a concentrated source of protein for sensory and functional properties in the final application process to meet nutritional value. Condensed milk protein serves as an alternative to whole milk powder (WMP), skim milk powder (SMP) and other milk powders, providing the same protein, or as a non-fat milk solid (MSNF). Compared with ordinary milk or skim milk powder, concentrated milk protein with high protein, low lactose characteristics.

The traditional ultra-high temperature sterilization process will destroy many of the active nutrients in milk but low-temperature ceramic membrane filtration technology completely subvert the traditional high-temperature sterilization of milk. The process of milk filtration and clarification is to make natural fresh milk fluid through dairy ceramic membrane technology and avoid heat denaturation of the protein, fully retain 99% of active immunoglobulin and 95% of lactoferrin and a variety of natural vitamins, milk calcium, minerals and trace elements and other nutrients in the state of low temperature and ensuring safety at the same time.

 BACTERIAL REMOVAL FROM MILK

Like many foods, milk and its derivatives provide a suitable environment for spoilage microorganisms. Therefore, pretreatment and temperature, time parameters must be selected to control the growth of microorganisms. Heat treatment and centrifugal sterilization are the traditional methods of reducing total number of bacteria in milk and dairy products, but these methods have their own advantages and disadvantages. Traditional techniques to remove bacteria in milk have more steps and high cost, short life, environmental pollution, inconvenient cleaning. However, the ceramic membrane filtration of milk can well solve these problems.

Membrane separation technology is used to eliminate bacteria in milk, which is based on the fact that the membrane has different material retention rates in various components of milk, including bacteria and spores. Bacteria can make the rejection rate of more than 99%, while casein transmittance can reach about 99%.

Membrane separation technology has a good membrane flux and sterilization effect, can completely remove bacteria in liquid milk, at the same time the flavor of milk has also been improved.

Membrane separation technology for cold sterilization is the method of fresh milk is  preheated to about 50 degrees and skim milk is got through milk cream separation machine. Then on the same day fresh skim milk makes filtration sterilization, combining with high-temperature instantaneous sterilization technology, to access to high quality dairy products. Such low-temperature sterilization retains a good flavor and nutrients, rich aroma.

Moreover, membrane cleaning is much easier to regenerate, so that membrane fouling can be controlled and a higher and more stable membrane flux can be maintained. The use of membrane separation technology for cold sterilization of milk, functional components can be retained during the re-separation activity, is an ideal method of sterilization of milk.

 BACTERIAL REMOVAL FROM WHEY CASEIM

Casein is the basic component df ordinary cheese. In the cheese making process, casein is precipitated by the action of rennet enzymes,and a coagulum is formed consisting of casein,whey proteins,fat,lactose and the minerals of the milk.

Membrane separation technology is used to eliminate bacteria in milk, which is based on the fact that the membrane has different material retention rates in various components of milk, including bacteria and spores.Bacteria can make the rejection rate of more than 99%, while casein transmittance can reach about 99%.

JIANGSU JIUWU HI-TECH CO. LTD.,founded in 1997, focus on producing Organic membrane filters for many years. And JIUWU HI-TECH has become a leading company in the membrane separation industry. We sincerely invite and welcome people from all around the world to invest and create more values together.

Eolane SCM supplies:

EL back light membrane switch panel

Flat membrane switch

FPC membrane switch

Graphic overlay

LED membrane switch

Copper circuit on PC and PET materials

Options for membrane switch we usually adopt:

No tactile feeling when pressing.

More than 5 million times’ actuation life.

Can be embedded LEDs, inserted EL or EMI/ESD/RFI Shielding layer.

Metal Dome in switch

Offer good click feeling when pressing

More than 1 million actuation

Poly dome in switch

Has similar click feeling and longer actuation life comparing metal dome.

Cost effective competing metal dome.

There are other options for membrane switch, such as embedded LED, inserted EL back light layer, inserted ESD or EMI/RFI shielding layer and sealed structure (water proof function）

Want to know more about china membrane keypad? Don’t hesitate to contact us.

JIUWU company produces the ceramic ultrafiltration membranes with the pore size 20nm, 50nm and so on. JIUWU company offers a large choice of ceramic uf membranes with different geometries and cut-offs to meet your process requirements in viscosity, molecule size, impurity profile, purity and yield target, etc. as well as cleaning and sanitization procedures. Ceramic ultrafiltration membranes are better than those membranes in ceramic membrane filtration systems. Our UF membrane water filter won't let you down!

OVER VIEW OF ULTRAFILTRATION CERAMIC MEMBRANE ELEMENT

Ultrafiltration ceramic membrane/ceramic filter is a variety of membrane filtration in which forces, such as pressure or concentration gradients, cause separation through the semi-permeable membrane. High molecular weight suspended solids and solutes remain in the so-called retentate while water and low molecular weight solutes pass through the membrane in the permeate (filtrate). The pore size of the ultrafiltration ceramic membrane is in the range of 0.01μm ~ 0.05μm, suitable for the separation, concentration, and purification of macromolecules and small molecules.

A versatile and economical solution for clarification, concentration, and purification of liquids, ultrafiltration membrane filter could remove emulsified oils, metal hydroxides, colloids, bacteria and viruses, emulsions, dispersed material, suspended solids, and other large molecular weight materials from water and other solutions. Ultrafiltration ceramic membrane also serves in critical parts of the production processes of fruit juice, milk and whey, electrocoat paints, pharmaceuticals, poly-vinyl alcohol, and indigo dye. It is key to surface water treatment for potable uses and wastewater treatment for reuse, such as palm oil wastewater and paper mill wastewater treatment. Ultrafiltration ceramic membrane is used to recycle flow or add value to later products and more. In many cases, ultrafiltration ceramic membrane is used for prefiltration in reverse-osmosis plants to protect the reverse-osmosis process. Ultrafiltration ceramic membrane is an effective means of reducing the silt density index of water and removing particulates that can foul reverse osmosis membranes.

APPLICATION OF ULTRAFILTRATION CERAMIC MEMBRANE ELEMENT

Food & beverage

Bio-pharm

Chemical and petro-chemical

Water & wastewater treatment

ADVANTAGE OF ULTRAFILTRATION CERAMIC MEMBRANE ELEMENT

High flux

Reliability

Well-proven long operating life

Ease of use, clean, regenerate

Stable over a wide pH (0-14) range and chemical compatibility

Sterilization by steam and oxidizing agents

Wear ability and excellent strength

Narrow pore size distribution

Stringent quality control process and procedures with full trace ability

Excellent performance in MF/UF & thermal stability

To know more information about uf membrane filter price and microfiltration membrane price, please feel free to contact us!

Ultrafiltration (UF) is a variety of membrane filtration in which forces, such as pressure or concentration gradients, cause separation through the semi-permeable membrane. High molecular weight suspended solids and solutes remain in the so-called retentate while water and low molecular weight solutes pass through the membrane in the permeate (filtrate). The pore size of the ultrafiltration membrane is in the range of 0.01μm ~ 0.05μm, suitable for the separation, concentration and purification of macromolecules and small molecules.

Application of Ceramic ultrafiltration Membrane 

UF technology can be used to remove particulates and macromolecules from raw water to produce potable water. It has been used to replace the existing secondary (coagulation, flocculation, sedimentation) and tertiary filtration (sand filtration and chlorination) systems used in water treatment plants or as stand-alone systems in isolated areas with a growing population.

When treating water containing highly suspended solids, primary (screening, flotation and filtration) and some secondary treatments are often used as a pretreatment stage to incorporate ultrafiltration into the process.

When water recovery is simple, very little processing is often required. However, when more in-depth processing is required, industry standard procedures include the use of UF membrane technology, which means removing the physical solids from the water by passing them through a semipermeable membrane. With ultrafiltration, the solids are primarily captured by the filter and discarded.

Circulating water can also be used in a variety of industrial applications including water supply to boilers or cooling towers, pH control, cleaning equipment, hard beds and vehicles, fire fighting, rinsing or process water for manufacturing industrial lines, toilet flushing, dust control, construction activities Mix with concrete.

Ultrafiltration is often used to pre-treat surface water, seawater and bioprocessed municipal water upstream of reverse osmosis plants.

Industries that consume large amounts of water or discharge highly toxic wastewater may use ultrafiltration to recover water.

These include chemicals, steel, plastics and resins, paper and pulp, pharmaceutical and food and beverage industries, including soft drinks and canned foods, and electricity, water and wastewater treatment plants.

Ultrafiltration is used to recycle flow or add value to later products and more. In many cases ultrafiltration (UF) is used for prefiltration in reverse-osmosis plants to protect the reverse-osmosis process. Ultrafiltration is an effective means of reducing the silt density index of water and removing particulates that can foul reverse osmosis membranes.

Features of Ultrafiltration Membrane

Ultrafiltration processes are preferred over traditional treatment methods for the following reasons:

• No chemicals required (aside from cleaning)
• Constant product quality regardless of feed quality
• Compact plant size
• Capable of exceeding regulatory standards of water quality, achieving 90-100% pathogen removal.

The SS ceramic membrane module is designed by different applications. Stainless steel could be used as the material of module/housing, that is, ss membrane housing. 

JIUWU company could produce the extra large stainless steel membrane housing as customer demand, such as loading over 91 pcs membranes. It also can be 1, 3, 7, 12, 19, 37, 61, 76, 91, 138, 241 pcs membranes.

OVER VIEW OF SS CERAMIC MEMBRANE HOUSING

Ceramic membrane element has a variety of narrow distribution, high porosity, high capacity per unit membrane surface area. 

Ceramic membrane element needs to be used and operated in normal operating procedures. The following conditions and chemicals of operation are absolutely not allowed, because it may destroy or damage the element:

Sharp variations in pressure;

Vigorous variations in temperature, △≤5℃/min;

Meet with strong acid and alkali with high concentration and temperature in a long time such as hydrofluoric acid, sulphuric acid ,hydrochloric acid in combination with stainless steel housings, formic or acetic acid at high concentration and high temperature, silicates, acrylics, varnish, silicon soil, resins, wax;

Filtering high viscosity liquid or liquid containing large rigid solid granules;

Using pumps without a soft starter or frequency converter;

Strike or knock on purpose;

CHARACTERISTICS OF STAINLESS STEEL MEMBRANE HOUSING

Number of loading membrane elements: 1, 3, 7, 12, 19, 37, 61, 76, 91, 138, 241 pcs

Matching membrane element length Diameter: 500, 1000, 1200mm / diameter: 25, 30, 40 mm

Main body material: SUS304 (L), SUS316 (L)

Sealing material: EPDM, Fluoro Rubber, Silicon, PTFE

Interface: Flange, Clamp, Whorl coupling

Pressure level: 0-1.0Mpa, 0-1.6Mpa, 0-2.5Mpa, 0-4.0Mpa

Standard: ISO, DIN / chemical grade, sanitary grade

APPLICATION OF SS CERAMIC MEMBRANE HOUSING

1. Food & Beverage

Sweetener

Wine (beer membrane filtration)

Fruit and vegetable juice

Dairy

Flavoring and seasoning

Natural herb extract

Enzyme

2. Bio-Pharm

Fermentation broth-antibiotic (including purification of antibiotics)

Fermentation broth-amino acid

3. Chemical and Petro-Chemical

Natural rubber (skim latex)

polysolicon cutting fluid recovery

Brine filtration

4. Water & Wastewater Treatment ( ceramic membranes for wastewater treatment )

Oilfield injection water

Paper industry wastewater treatment

Textile and printing industry wastewater

Oily wastewater treatment

Titanium dioxide water treatment

Pharmaceutical/chemical industry wastewater

Desalination/seawater treatment

Landfill leachate

Degreasing liquid treatment

Palm oil wastewater

RO membrane technology is a water purification technology that uses a semipermeable membrane to remove ions, molecules, and larger particles from drinking water.

In reverse osmosis, an applied pressure is used to overcome osmotic pressure, a colligative property, that is driven by chemical potential differences of the solvent, a thermodynamic parameter.

The reverse osmosis membrane technology can remove many types of dissolved and suspended species from water, including bacteria, and is used in both industrial processes and the production of potable water. The result is that the solute is retained on the pressurized side of the membrane and the pure solvent is allowed to pass to the other side. To be "selective", this membrane should not allow large molecules or ions through the pores (holes) but should allow smaller components of the solution (such as solvent molecules) to pass freely.

Advantages of reverse osmosis

1. Removes nonionic impurities and dissoved solids (i.e.organics,silica,bacteria)
2. Reduction of hazardous chemical storage and handling associated with ion exchange
3. Reductes loading on ion exchange systems:

• Extends run lengths
• Extends resin life
• Reductes operating costs

Application range of reverse osmosis

• • Desalination
  • Dehydration
  • Concentration
  • Remove COD/BOD

OMS skid-mounted (Organic Membrane Filtration System) refers to a form of overall combination of equipment frame and whole equipment. Organic membrane system means that a group of equipment is fixed on the chassis and can be used after moving. It is not necessary to install valves and instruments in the middle, and it can be used by directly connecting the pipelines. OMS skid-mounted device is widely used in reverse osmosis (RO), Nanofiltration (NF), Ultrafiltration (UF) and Microfiltration (MF). OMS skid-mounted device is customized design to evaluate the performance applied in RO, NF, UF& MF.

OVER VIEW OF OMS SKID- MOUNTED DEVICE

OMS skid-mounted device is to meet the needs of researchers and end users through customization. OMS skid-mounted device is provided as a single or multiple-sets configurations in parallel and in series mode. OMS skid-mounted device is an automatic integrated device designed according to the user's requirements. According to the user's standardized design and digital management requirements, we offer OMS skid-mounted device which meets the user's on-site production requirements and process conditions. 

OMS skid-mounted device can achieve the purpose of data remote transmission and unattended with the remote intelligent terminal control system.OMS skid-mounted device is flexible and is designed different functions according to different user's requirements.

APPLICATION OF OMS SKID- MOUNTED DEVICE

Food and beverage processing

Bio-pharm processing

Seawater or brackish desalination

Juice and extract concentration (e.g. fruit juice membrane)

Industrial wastewater treatment or purification

Brine purification

Boiler industry water

Landfill leachate treatment

Water reuse in power plant

Flushing water purification

Printing and textile wastewater (e.g. dye wastewater treatment)

FEATURES OF OMS SKID- MOUNTED DEVICE

Modular- membrane elements, modules, power part, control and electrical part, pipeline, tank, instrumentation as well as structural and mechanical parts are designed in a package mode;

Charge substantial savings-All the design combined with basic process and on-site condition are fully considered ;

Reasonable layout- Modular or package unit design fully meets on-site operation requirements;

Upgrade fabrication and on-site installation - packaged equipment is inherently less complex to install and commission.

Good quality control-The modular manufacturer assumes full responsibility and can correct any system errors that may be easily discovered.

Fast data collection -All the data including flow rate, pressure, temperature， conductivity, and other relevant parameters are displayed in digital and recorded and tracked.

RF heat sealing equipment uses the friction heat generated on the contact surface of two workpieces to be welded to melt the plastic. Heat energy comes from a certain pressure, a workpiece on another surface with a certain displacement or amplitude reciprocating movement. Once the desired degree of embossing is achieved, the vibration will stop, but there will still be a certain amount of pressure on the two workpieces, so that the just embossed part of the cooling, curing, thus forming a close combination.

Characteristics of RF heat sealing equipment

1. High frequency thermal sealing equipment anti-wave interference device: high frequency stabilizer and high frequency magnetic field shielding system device, to minimize the high frequency interference, effectively solve the impact of high frequency interference on other machines or residents.

2. RFsealing equipmentweek stability: the use of international industrial band 27.12MHZ, stable output cycle, in line with the international industrial band standard.

3. RFsealing machinesoutput force is strong, reliable performance: low loss coaxial oscillator, with tuner, strong output force shorten welding time, improve output.

4. RF heat sealing equipment high-sensitivity spark arrester: relay, detection of excessive current.

5. Safety performance: in the work or static, whether it is suddenly encountered power failure or gas stop, or power or ventilation, the machine is stationary state, keep the original position, it will not suddenly rise or fall; Greatly improve the safety of workers operating problems.

6. RF heat sealing equipment heating device: stepless heating thermostat, according to the production needs of different products, may adjust the temperature, let the working efficiency is higher.

7. RF heat sealing equipment automatic over-current protection system: automatic over-current protection system, can increase the service life of the vacuum tube, protect the mould. Can choose direct or indirect oiling pressure oiling pressure. The output force is strong and the machine structure is solid. Double station foot control, convenient and quick, special mechanical structure, high output pressure.

8.RF heat sealing equipment is easy to high-speed tuner: the output power can be adjusted by the tuner depending on the size of the electrode and material thickness, with the exception of a variety of control devices and special electronic circuit, can greatly reduce the necessary welding time, improve the production of the machine.

Nanofiltration (NF) or nanofiltration membrane technology is a relatively recent membrane filtration process used most often with low total dissolved solids water such as surface water and fresh groundwater, with the purpose of softening (polyvalent cation removal) and removal of disinfection by-product precursors such as natural organic matter and synthetic organic matter.

The membranes are key to the performance of NF systems. They are produced in spiral wound, tubular, and hollow fiber formats, from a range of materials, including cellulose derivatives and synthetic polymer.

NF membranes have pore sizes from 1-10 nanometers, smaller than that used in microfiltration and ultrafiltration, but just larger than that in reverse osmosis.

Application range of NF Membrane Technology 

• Desalination & purification
• Dehydrated, concentrated
• Decolor
• Solvent recovery

Ceramic Nanofiltration membrane is relatively recent membrane filtration system, with the purpose of softening and removal of disinfection by-product precursors such as natural organic matter and synthetic organic matter. More ultrafiltration membrane system details here!

CHARACTERISTICS OF NANOFILTRATION CERAMIC MEMBRANE ELEMENT

Chemical, mechanical and thermal stability

Ability of steam sterilization and back flushing

High abrasion resistance

High fluxes

High durability

Bacteria resistance

Possibility of regeneration

Dry storage after cleaning

OVER VIEW OF NANOFILTRATION CERAMIC MEMBRANE ELEMENT

Ceramic nanofiltration membrane is widely used in petroleum and chemical industry, medicine, metallurgy and other processes involving harsh systems due to its unique thermal stability and chemical stability, resistance to organic solvents, disinfection, regeneration, and backwashing. In the industrial field, ceramic membrane system has become one of the fastest growing and most promising membrane materials in the membrane field.

1. Nanofiltration technology

Nanofiltration membrane technology is a new type of pressure-driven separation technology between ultrafiltration and reverse osmosis. It can not only effectively separate the relative molecular mass of 200-1000 by sieving, but also generate the Donnan effect by electrostatic action, with high removal rate for divalent and high valence ions.

In recent years, nanofiltration technology has gradually occupied an important position in the petrochemical, food processing, wastewater treatment, medical technology, and energy industries, and is a common technology for achieving sustainable development.

2. Ceramic nanofiltration membrane

Nanofiltration membrane materials are a key core of nanofiltration technology. Ceramic nanofiltration membrane has excellent thermal stability, chemical stability, high mechanical strength, acid and alkali resistance, microbial erosion, chlorine and other oxidizing substances, anti-pollution, etc. It has become the fastest growing and most developed in the membrane field and one of the prospective membrane materials.

APPLICATION OF NANOFILTRATION CERAMIC MEMBRANE ELEMENT

1. Chemical industry (membrane technology in the chemical industry)

a. Application in catalyst recovery in the petrochemical industry

In petrochemical and chemical production, the application of the catalyst is very extensive, and it is generally necessary to separate the product and the catalyst after the reaction. Ceramic nanofiltration membrane has good heat resistance, chemical solvent resistance, and good mechanical strength. It adopts cross-flow filtration method in catalytic reaction solid-liquid separation and has the advantages of high-temperature resistance, acid and alkali resistance, solvent resistance, etc. The coupling can fully improve the efficiency of the reactor, high separation precision, and can separate the nano-scale catalyst.

b. Application in brine purification in the field of the chlor-alkali chemical industry

Ceramic nanofiltration membrane has excellent performance such as pollution resistance and long life and is widely used in the field of chlor-alkali chemical industry. Using efficient "cross-flow" filtration, it is difficult to achieve results and advantages with other refining and filtration technologies.

2. Fine separation of medicine

Compared with traditional organic membranes, ceramic composite nanofiltration membranes have the unique advantages of high separation precision, guaranteed filtrate quality, high flux filtration, high product yield, low wastewater, low cleaning frequency and no need for additives. It can realize desalting and pre-concentration of target products and has been successfully applied to biological enterprises such as glutamic acid, citric acid, itaconic acid, and vitamin C.

3. Environmental water treatment (water filtration membrane)

The integrated process with ceramic membrane + organic membrane as the core is widely used in: oily water filtration system, metallurgical wastewater treatment, chemical wastewater treatment, paper mill wastewater treatment, large-scale pure water and ultrapure water preparation, zero discharge of power plant brine.

4. Gas purification

The integrated process technology with ceramic nanofiltration membrane as the core has the unique advantages of high separation precision, short process, acid and alkali resistance, high-temperature resistance and pollution resistance. It is widely used in industrial flue gas desulfurization, blast furnace solid-gas separation and automobile exhaust gas treatment. Wait.

5. New materials field

The ceramic nanofiltration membrane can effectively remove impurity ions in the slurry and efficiently prepare ultrafine ultra-pure nano-powder. At present, it has been applied to the purification of nano-powders such as nano-catalysts and ultra-pure non-ferrous metals. It can also be used in the purification process of nano-materials such as lithium batteries and graphene so that the impurity components in the production process can be removed in time, which is beneficial to the improvement of product yield.

Ceramic membranes (Porous Ceramic Membrane & tubular ceramic membrane) are available for microfiltration, ultrafiltration and nanofiltration as single-channel or multiple-channel elements with channel diameters between 2 and 16mm.

Contact us now for more details about China membrane and the ceramic membrane price!

The principle of porous tubular ceramic membrane

The principle of the filtration is based on two opposing effects: on the one hand, the particles are transported by the filtration flux to the membrane where they cause an increase in concentration; on the other hand, concentration differences are again reduced by the turbulence of the cross-flow and by Brownian motion of the particles. Ceramic membrane separation has greatly improved work efficiency and quality.  

During filtration by means of ceramic membranes made by JIUWU ceramic membrane manufacturer, the medium to be filtered flows through the channels of the membrane support. All particles whose size exceeds the pore radius of the membrane are retained. The particles /molecules build up in the concentrate. The filtrate permeates through the pores and depending on the procedure is subjected to subsequent process stages. This filtering method is also called "cross-flow filtration" or "dynamic filtration". Cross-flow management can achieve stable fluxes. Still, the cleaning of cross-flow installations needs to be applied from time to time. Cleaning is performed by means of backward flushing or chemical cleaning. There are various ceramic membranes for water treatment in the market, while JIUWU ceramic membranes for wastewater treatment perform very well. Learn more about  pilot ceramic membrane technology and ceramic membrane design here! 

The principle of cross-flow filtration in porous tubular ceramic membrane

The membrane area of CMP pilot machine has the following types: 
0.1 m², 0.2 m², 0.5 m², 1 m², 2 m², 3 m², 4.5 m², 5 m², 6 m², 6.5 m², 8 m², 9 m²

Skid-mounted device (Ceramic Membrane Filtration System) effectively allocates and stores machine for process and modular systems in the field of solid-liquid separation. A CMF skid-mounted device is designed by order and fully optimized as process flow, which includes CMF unit, power part, control part and supporting pipelines, valves and instruments. The device can be designed as a containerized device.