Tibolone Basic Info
Product name: Tibolone
Alias: LIVIELLA; LIVIAL
CAS: 5630-53-5
EINECS: 227-069-1
Assay: 99% min.
MF: C21H28O2
MW: 312.45
Appearance: White or off-white crystal powder
Grade: Pharmaceutical Grade
Storage: Shading, confined preservation
Usage: It is a synthetic hormone-type drug which is used mainly for hormone replacement therapy in post-menopausal women.
Tibolone Product Detail
Tibolone, sold under the brand names Livial and Tibofem among others, is a medication which is used in menopausal hormone therapy and in the treatment of postmenopausal osteoporosis and endometriosis. The medication is available alone and is not formulated or used in combination with other medications. It is taken by mouth.
Side effects of tibolone include acne and increased hair growth among others. Tibolone is a synthetic steroid with weak estrogenic, progestogenic, and androgenic activity, and hence is an agonist of the estrogen, progesterone, and androgen receptors. It is a prodrug of several metabolites. The estrogenic effects of tibolone are selective to certain tissues, with such effects in bone, the vagina, and the brain, but not in the uterus, breast, or liver.
Tibolone was developed in the 1960s and was introduced for medical use in 1988. It is marketed widely throughout the world, for instance in Europe. The medication is notably not available in the United States or Canada. It is a controlled substance in Canada, with the classification of an anabolic steroid.
Tibolone Application
All the information we provide is for reference only, please use drugs according to professional advice
Tibolone is used in the treatment of menopausal symptoms like hot flashes and vaginal atrophy, postmenopausal osteoporosis, and endometriosis. It has similar or greater effectiveness compared to older menopausal hormone therapy medications, but shares a similar side effect profile. It has also been investigated as a possible treatment for female sexual dysfunction.
Tibolone reduces hot flashes, prevents bone loss, improves vaginal atrophy and urogenital symptoms (e.g., vaginal dryness, dyspareunia), and has positive effects on mood and sexual function.The medication may have greater benefits on libido than standard menopausal hormone therapy, which may be related to its androgenic effects. It does not cause increased endometrial proliferation and is associated with low rates of vaginal bleeding and breast pain.
A 2015 network meta-analysis of randomized controlled trials found that tibolone was associated with a significantly decreased risk of breast cancer (RR = 0.317). The decrease in risk was greater than that observed with most of the aromatase inhibitors and selective estrogen receptor modulators that were included in the analysis. However, paradoxically, other research has found evidence supporting an increased risk of breast cancer with tibolone.
Tibolone Side Effects And Prevention
A report in September 2009 from Health and Human Services' Agency for Healthcare Research and Quality suggests that tamoxifen, raloxifene, and tibolone weight loss used to reduce the risk of breast cancer significantly reduce the occurrence of invasive breast cancer in midlife and older women, but also increase the risk of adverse effects.
Tibolone can produce androgenic side effects such as acne and increased facial hair growth. These side effects have been found to occur in 3 to 6% of treated women.
A 2016 Cochrane review has been published on the short-term and long-term effects of tibolone, including adverse effects.
Tibolone Order Process
- email or whatsapp us about what you need,quantity and destination.
- we would answer your email in 12 hours with our best price.
- If you think the price is workable, we would send you our payment information.
- After we received your payment ,we would arrange the shipping for you
- You would receive our package in 7-10 working days.
Tibolone Our Advantage
- Top Quality in the market, most product have the purity of 98%+ and some beyond 99%
- Competitive price, we offer speical discount for large amount order.
- Fast shipping ,we would deliver your product in 7-10 working days.
- Free Re-shipping, we promise that you will receive your package
- Security, we will not transfer any of your info to any third party.
