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1.Basic information of All trans-Retinal

Product Name: All trans-Retinal

Other Names: Retinylaldehyde, Axerophthal

Appearance: yellow crystals or powder

Test Method: HPLC

CAS NO .: 116 31 4

Molecular formula: C20H28O

Molecular weight: 284.44

Melting Point: 61-63℃

Identification: Infrared absorption spectrum of test shall be consistent with the standard

Solubility: Dissolved in ethanol, chloroform, cyclohexene Alkanes, petroleum ether, oil. not  dissolve in water.

Packaging Detail: 10gram/aluminium foil bag or 25kg/aluminium can (or as per customer’s request.)

Shelf Life: 1 year

Specification:98% by HPLC

2.Introduction of All trans-Retinal

All-trans-Retinal (Retinaldehyde, RAL), also known as vitamin A aldehyde, is retinol oxidized derivatives, It is produced by oxidation fracture of beta-carotene, which is reduced to retinol and oxidized to retinoic acid. Retinoic acid has A wide range of functions in skin diseases, but due to local stimulation, Its clinical application was limited. Retinal is an intermediate metabolite of natural retinoic acid, which bio-activity is similar to retinoic acid, and the skin is significantly more resistant to it than retinoic acid.

The application of A large number of non-physiological doses of exogenous retinoic acid may lead to the excess of retinoic acid dependence pathways in the skin, which can cause skin irritation and other adverse reactions. RAL is A natural metabolite of retinol and direct the precursor substances of retinoic acid. It has similar biological activities to retinoic acid. RAL has the advantages over retinoic acid for its  "reverse metabolism", the excess RAL can be rapidly reduced to retinol, and storage or inactivation in the form of retinol, and this "reverse metabolism" does not exist in retinoic acid. After RAL is absorbed by the skin, most are converted into retinol vinegar and stored for slow releasing, while a small amount of RAL is oxidized to retinoic acid by keratinized cells in A differentiation dependent manner, and this very small amount of retinoic acid can play biological functions in cells. This can avoid the skin adverse reaction caused by high dose of vitamin A acid. Clinical obeservation is also shown that RAL cream has better tolerance than retinoic acid and can be applied to sensitive parts. External used RAL was not absorbed into human blood, and the levels of various retinoids in the blood were also not affected by the external used RAL.

Main Functions of All trans-Retinal

1.  Repair the loss of elastic fibers and collagen caused by UV
2. Anti-aging skin caused by ultrasound and fluid technology
3. Effectively improve the skin photoaging symptoms
4. Retinol and retinal have good tolerance, but retinoic acid is more irritating
5. Effectively inhibit epidermal melanin
6. Acne treatment: kill acne propionitis and streptococcus, cure acne, reduce acne marks

7. Reduce pigment deposition, whiten and remove spots

Certificate of Analysis

Product Name:  Retinal          Test Standard: Enterprise standard

CAS No.: 116-31-4              Batch NO.: 20170728RAL 

Quantity:5KG     Manufacture Date: 07-28-2018                                         Test Date: 07-29-2018             Expiry Date: 07-27-2019

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